Population and Epidemiological Aspects of Carriage of Toxigenic (Cd tox+) and Non-toxigenic (Cd tox-) Diphtheria corynebacteria

Relevance. It is known that antitoxic immunity saves from diphtheria, but does not prevent the carriage of Cd (tox+). Asymptomatic carriers (tox+) play a major role in maintaining epidemiological process diphtheria infection. Aims. Characteristics population composition and specifics kinetic reactions (tox-) simultaneously functioning among people. Results. The functional features specific individual populations an important existence microbial human biotopes. introduction corinephage tox+ gene into symbiotic promoted synthesis toxin adaptive stability environment. Metabolites - autostabilizers growth form microecological systems Conclusions. use metabiotic drug Kodivac allows: to treat long-term (tox+); reduce circulation population; together with small doses toxoid create protection against diphtheria; symbiogenesis biotopes, suppressing dysbiotic inflammatory reactions.